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Relating Stomatal Conductance to Leaf Functional Traits
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High-Diversity Mouse Populations for Complex Traits.

Michael C Saul1, Vivek M Philip1, Laura G Reinholdt1

  • 1The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.

Trends in Genetics : TIG
|May 29, 2019
PubMed
Summary
This summary is machine-generated.

Advanced mouse genetic populations like the Collaborative Cross (CC) and Diversity Outbred (DO) enable discovery of complex disease mechanisms. These high-diversity resources harness genetic variation for precise identification of disease pathways relevant across species.

Keywords:
complex geneticscomplex traitsgenetic diversitymousesystems genetics

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Area of Science:

  • Genetics
  • Genomics
  • Systems Biology

Background:

  • Contemporary mouse genetic reference populations are crucial for understanding complex disease mechanisms.
  • High-diversity populations such as the Collaborative Cross (CC) and Diversity Outbred (DO) stocks, along with their isogenic founder strains, represent advanced resources.

Purpose of the Study:

  • To highlight the utility of high-diversity mouse populations in systems genetics and integrative genomics.
  • To emphasize the efficient harnessing of genetic variation for precise and contextualized identification of complex disease mechanisms.

Main Methods:

  • Utilizing systems genetics and integrative genomics analyses.
  • Leveraging extensive genetic, genomic, and phenotypic data available for these mouse populations.
  • Employing a growing suite of data analysis tools developed for diverse mouse research.

Main Results:

  • These populations efficiently identify complex disease mechanisms by harnessing known genetic variation.
  • The integrated resource facilitates the discovery and evaluation of disease mechanisms.

Conclusions:

  • High-diversity mouse populations provide a powerful platform for discovering complex disease mechanisms.
  • The available data and analysis tools support research on diverse mice, enabling cross-species relevant discoveries.