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Updated: Jan 24, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Frontier Between Cyclic Peptides and Macrocycles
Philipp Ermert1, Anatol Luther2, Peter Zbinden2
1Polyphor Ltd., Allschwil, Switzerland. philipp.ermert@polyphor.com.
Abstract:
This review describes a selection of macrocyclic natural products and structurally modified analogs containing peptidic and non-peptidic elements as structural features that potentially modulate cellular permeability. Examples range from exclusively peptidic structures like cyclosporin A or phepropeptins to compounds with mostly non-peptidic character, such as telomestatin or largazole. Furthermore, semisynthetic approaches and synthesis platforms to generate general and focused libraries of compounds at the interface of cyclic peptides and non-peptidic macrocycles are discussed.
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