Related Experiment Video
Updated: Jan 24, 2026
08:11
Measuring Caenorhabditis elegans Sensitivity to the Acetylcholine Receptor Agonist Levamisole
Published on: June 7, 2022
4.5K
Levamisole-Induced Vasculitis in the Lower Extremities: A Case Report
Summary
Levamisole-induced vasculitis, often seen in the head and neck, can also cause painful lower-extremity ulcers. Early identification and treatment with wound care and cocaine cessation are crucial for healing.
Area of Science:
- Dermatology
- Toxicology
- Vascular Medicine
Background:
- Levamisole, historically an immunomodulator, is now used in veterinary medicine and illicitly as a cocaine additive.
- Increased reports of agranulocytosis and vasculitis linked to levamisole use since 2006.
- Levamisole-induced vasculitis typically affects the head and neck, with fewer documented cases in lower extremities.
Observation:
- A 60-year-old woman presented with painful lower extremity ulcerations.
- Physical examination and laboratory results ruled out infection.
- Radiographs and punch biopsy were performed.
Findings:
- The patient's ulcers showed no signs of infection.
- Treatment involved local wound care and counseling on cocaine cessation.
- Continued cocaine use impeded ulcer healing.
Implications:
- Levamisole-induced ulcers can present pathognomonically in the lower extremities.
- Prompt identification by podiatric physicians is vital for effective management.
- Optimal treatment requires local wound care, cocaine cessation, and addiction therapy.
Related Concept Videos
01:22Absolute and Local Extreme Values
59
The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
59
01:24Data Reporting and Recording
5.4K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
01:25Types of Reports I: Hands-off Report
1.5K
A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
01:21Types of Reports II: Incident or Occurrence Report
1.2K
An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.2K
01:26Types of Reports III: Telephone and Verbal Reports
1000
Telephone and Verbal Reports in healthcare settings are two communication methods for conveying therapeutic instructions from healthcare providers to nurses or other healthcare staff.
Here's an overview of each type:
Telephone Orders
Here's an overview of each type:
Telephone Orders
1000
02:11Reporter Genes
13.1K
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
13.1K