Safe, Effective Chin and Jaw Restoration With VYC-25L Hyaluronic Acid Injectable Gel

Area of Science:

• Dermatology
• Plastic Surgery
• Aesthetic Medicine

Background:

• VYC-25L is a hyaluronic acid-based soft-tissue filler containing lidocaine.
• It is specifically formulated for restoring and augmenting facial volume, particularly in the chin and jaw areas.

Purpose of the Study:

• To assess the safety and efficacy of VYC-25L in individuals experiencing chin retrusion.
• To evaluate the impact of VYC-25L on the glabella-subnasale-pogonion facial angle.

Main Methods:

• A randomized controlled trial involving 119 adults with chin retrusion (145°-165° facial angle).
• Participants were randomized (3:1) to receive VYC-25L at study onset or a delayed treatment at 3 months.
• Primary endpoint was the mean change in facial angle at Month 3; safety was monitored via injection site responses and adverse events.

Main Results:

• VYC-25L significantly improved the mean facial angle by 2.51° (p < .0001) at Month 3 compared to the control group.
• High patient satisfaction was reported, with sustained benefits observed up to Month 12.
• Common side effects included temporary firmness, tenderness, and swelling; no serious adverse events were reported.

Conclusions:

• VYC-25L is a safe and effective treatment for correcting chin retrusion.
• The hyaluronic acid filler significantly enhances facial aesthetics and is well-tolerated by patients.