Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sustainable Development01:43

Sustainable Development

14.8K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.0K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.0K
Language Development01:22

Language Development

878
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
878
Development of the Heart01:27

Development of the Heart

2.3K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
2.3K
Development of Immunocompetence01:22

Development of Immunocompetence

809
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
809
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.1K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated analysis of insulin resistance reveals metabolic remodeling following diet switch-triggered calorie reduction.

Science advances·2026
Same author

Evaluating the therapeutic impact of tirzepatide in people with partial lipodystrophy.

The Journal of clinical endocrinology and metabolism·2026
Same author

Insulin resistance prediction from wearables and routine blood biomarkers.

Nature·2026
Same author

Dynamic subcellular proteomics identifies regulators of adipocyte insulin action.

Nature communications·2026
Same author

Epidemiological and clinical data from the European Lipodystrophy Registry.

European journal of endocrinology·2025
Same author

Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health.

Nature genetics·2025

Related Experiment Video

Updated: Jan 24, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney
11:29

Technique to Target Microinjection to the Developing Xenopus Kidney

Published on: May 3, 2016

12.0K

Recent developments in lipodystrophy.

Audrey Melvin1,2, Anna Stears2, David B Savage1,2

  • 1Metabolic Research Laboratories, Wellcome Trust - MRC Institute of Metabolic Science, University of Cambridge.

Current Opinion in Lipidology
|May 29, 2019
PubMed
Summary
This summary is machine-generated.

Recent research on lipodystrophy syndromes offers new insights into rare genetic disorders. Studies explore genetic mutations, therapeutic targets, and links between lipodystrophy and metabolic syndrome.

More Related Videos

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.9K
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
08:01

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

8.6K

Related Experiment Videos

Last Updated: Jan 24, 2026

Technique to Target Microinjection to the Developing Xenopus Kidney
11:29

Technique to Target Microinjection to the Developing Xenopus Kidney

Published on: May 3, 2016

12.0K
Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.9K
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
08:01

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

8.6K

Area of Science:

  • Endocrinology and Metabolism
  • Rare Diseases Research
  • Genetics and Molecular Biology

Background:

  • Lipodystrophy syndromes are rare, heterogeneous disorders presenting research challenges.
  • Understanding specific subtypes like familial partial lipodystrophy (FPLD) is crucial.
  • Genetic factors in lipodystrophy may offer insights into broader metabolic diseases.

Purpose of the Study:

  • To review recent advancements in non-HIV-associated lipodystrophy syndromes.
  • To highlight new findings on the genetic basis and natural history of lipodystrophies.
  • To discuss therapeutic implications and the role of genetics in lipodystrophy management.

Main Methods:

  • Literature review of recently published studies on lipodystrophy.
  • Analysis of genetic mutations (e.g., LMNA, PLIN1, PPARG) and their phenotypic effects.
  • Examination of therapeutic responses to leptin and pharmacogenetics.

Main Results:

  • LMNA mutations indicate adipose tissue phenotype precedes puberty in FPLD2.
  • PLIN1 variants challenge current understanding of perilipin 1's role in FPLD4.
  • PPARγ mutations show differential drug responsiveness, suggesting pharmacogenetic approaches.
  • Leptin has food-independent metabolic effects relevant to lipodystrophy.

Conclusions:

  • Lipodystrophy research advances understanding of rare genetic adipose tissue disorders.
  • Shared pathophysiology between lipodystrophy syndromes and metabolic syndrome is increasingly evident.
  • Genetic insights into lipodystrophy contribute to understanding metabolic disease in the general population.