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Updated: Jan 24, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
Published on: August 3, 2011
Can propranolol prevent progression of melanoma?
1Jason Kao is a student in the PA program at the University of California-Davis' Betty Irene Moore School of Nursing in Sacramento, Calif. Brent Luu is an assistant clinical professor in the Betty Irene Moore School of Nursing. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
The worldwide incidence of melanoma has risen rapidly in the past 50 years and is a considerable public health burden in the United States, with significant financial implications. Studies have demonstrated the potential anticarcinogenic effects of antihypertensive agents, specifically beta-blockers, in patients with prostate cancer, breast cancer, and lately cutaneous malignant melanoma. This article explores the empirical clinical evidence of propranolol's anticarcinogenic effects on melanoma and the chemoprotective mechanisms of beta-blockers and other agents that have been used to modify melanoma progression.
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