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Current state of the nanoscale delivery systems for temoporfin-based photodynamic therapy: Advanced delivery

Ilya Yakavets1, Marie Millard2, Vladimir Zorin3

  • 1Centre de Recherche en Automatique de Nancy, Centre National de la Recherche Scientifique UMR 7039, Université de Lorraine, Campus Sciences, Boulevard des Aiguillette, 54506 Vandoeuvre-lès-Nancy, France; Research Department, Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54519 Vandoeuvre-lès-Nancy, France; Laboratory of Biophysics and Biotechnology, Belarusian State University, 4 Nezavisimosti Avenue, 220030 Minsk, Belarus.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 29, 2019
PubMed

Insights

Photodynamic therapy (PDT) faces challenges with hydrophobic photosensitizers like temoporfin (mTHPC). Nanoparticle delivery systems are crucial for effective cancer treatment, with combined nanoplatforms showing promise.

Area of Science:

  • Oncology
  • Nanotechnology
  • Photochemistry

Background:

  • Photodynamic therapy (PDT) is a promising cancer treatment.
  • Hydrophobic photosensitizers, such as temoporfin (mTHPC), require effective delivery systems.
  • Current delivery methods for mTHPC have limitations.

Purpose of the Study:

  • To review challenges and achievements in nanoparticle-based delivery of temoporfin (mTHPC) for PDT.
  • To explore synergistic combinations of nanoplatforms for improved biodistribution.
  • To consider multi-modal treatment strategies using combined nanoplatforms.

Main Methods:

  • Literature review of nanoplatforms for mTHPC delivery.
  • Analysis of different nanoparticle types (conjugates, inclusion complexes, lipid/polymer nanoparticles, carbon nanotubes).
  • Focus on synergetic combinations and multi-modal approaches.

Main Results:

  • Numerous nanoplatforms have been developed for mTHPC delivery over 25 years.
  • No single nanoplatform has proven "ultimate" for mTHPC delivery.
  • Synergistic combinations and multi-modal nanoplatforms represent advanced strategies.

Conclusions:

  • Effective delivery of hydrophobic photosensitizers like temoporfin (mTHPC) is key to successful PDT.
  • Combining various nanoplatforms can enhance temoporfin delivery throughout biodistribution.
  • Integrated nanoplatforms offer potential for combined therapeutic modalities.
Keywords:
Drug deliveryHybrid nanodelivery systemsNanoparticlesPhotodynamic therapyTemoporfin

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