The race between drug introduction and appearance of microbial resistance. Current balance and alternative approaches
Esaú López-Jácome1, Rafael Franco-Cendejas2, Héctor Quezada3
1Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico; Laboratorio de Infectología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
Abstract:
As current levels of antimicrobial resistance are alarming, the World Health Organization urged the development of new antimicrobials to fight infections produced by multidrug resistant bacteria. Antibiotics impose severe selective pressure for the development of resistance, and currently bacteria resistant to all of them exist. In this review, we discuss the release and development of new antibacterial drugs and their properties as well as the current advances in the development of alternative approaches to combat bacterial infections, including the repurposing of drugs, anti-virulence therapies, the use of photosensitizers, phage therapy, and immunotherapies, with an emphasis on what is currently known about the possible development of bacterial resistance against them.
Related Concept Videos
In Vitro Drug Dissolution: Alternative Methods
Brick Durability, Strength, and Appearance
Balancing Redox Equations
RACE - Rapid Amplification of cDNA Ends
Impression Management Techniques I: Managing Appearances
Energy Balance


