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Integrin α3β1 Is Not Required for Onset of Dysplasia in Genetic Model of Colon Cancer but Promotes Motility of Colon Cancer Cells.

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Roles for epithelial integrin α3β1 in regulation of the microenvironment during normal and pathological tissue remodeling.

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Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

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Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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Integrin Regulation of CAF Differentiation and Function.

C Michael DiPersio1, Livingston Van De Water2

  • 1Department of Surgery, Albany Medical College, Albany, NY 12208, USA. dipersm@amc.edu.

Cancers
|May 30, 2019
PubMed
Summary
This summary is machine-generated.

Integrins regulate cancer-associated fibroblasts (CAFs) and their communication within the tumor microenvironment. Understanding integrin roles in CAFs is crucial for targeting tumor growth and progression.

Keywords:
cancer-associated fibroblast (CAF)extracellular matrixintegrinparacrine signalingtumor microenvironment

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • The tumor microenvironment is remodeled and activated by stromal cells, including cancer-associated fibroblasts (CAFs).
  • Integrins mediate cell adhesion and signal transduction, influencing tumor cell and stromal cell interactions.

Purpose of the Study:

  • To review the roles of integrins in regulating cancer-associated fibroblasts (CAFs) within the tumor microenvironment.
  • To explore how integrins control CAF functions and their response to extracellular cues.

Main Methods:

  • Literature review focusing on integrin functions in CAFs and myofibroblasts.
  • Analysis of integrin roles in cell adhesion, signal transduction, and paracrine communication.

Main Results:

  • Integrins regulate CAF-mediated extracellular matrix remodeling and signaling.
  • Integrins control CAF responses to tumor-derived signals and influence paracrine crosstalk.
  • Extensive literature on myofibroblast integrins provides insights into CAF functions.

Conclusions:

  • Integrins are critical regulators of cancer-associated fibroblast (CAF) behavior and their contribution to the tumor microenvironment.
  • Targeting integrins in CAFs may offer therapeutic strategies to inhibit tumor growth and progression.