Related Experiment Video

Updated: Jan 24, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

772

MicroRNA-664 functions as an oncogene in cutaneous squamous cell carcinomas (cSCC) via suppressing interferon

Xiangzhi Li1, Cheng Zhou2, Chen Zhang1

  • 1Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.

Journal of Dermatological Science
|May 30, 2019
PubMed
Abstract

Insights

MicroRNA-664 (miR-664) acts as an oncogene in cutaneous squamous cell carcinoma (cSCC) by promoting tumor growth and metastasis. Targeting miR-664 and its downstream target IRF2 may offer new therapeutic strategies for cSCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Aberrant microRNA-664 (miR-664) expression is implicated in various cancers.
  • The specific role of miR-664 in cutaneous squamous cell carcinoma (cSCC) remains unclear.

Purpose of the Study:

  • Investigate the molecular mechanisms of miR-664 in cSCC development.
  • Identify potential therapeutic targets for cSCC.

Main Methods:

  • Analyzed miR-664 and IRF2 expression in human cSCC specimens and cell lines.
  • Utilized cSCC cell lines and a mouse tumor model to study tumorigenesis.
  • Investigated the regulatory relationship between miR-664 and IRF2.

Main Results:

  • miR-664 was significantly upregulated in cSCC tissues and cell lines.
  • Overexpression of miR-664 enhanced cSCC cell proliferation, migration, invasion, and tumorigenicity in vivo.
  • IRF2 was identified as a direct downstream target of miR-664; its suppression by miR-664 drives cSCC progression.

Conclusions:

  • Aberrant miR-664 expression is a critical factor in cSCC carcinogenesis.
  • miR-664 functions as an oncogene in cSCC by suppressing IRF2.
  • miR-664 and IRF2 represent potential therapeutic targets for cSCC treatment.
Keywords:
CarcinogenesisCutaneous squamous cell carcinomasInterferon regulatory factor 2MetastasisMicroRNA-664Proliferation

More Related Videos

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

4.0K
Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression07:53

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

7.7K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.9K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

4.1K
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
624