Related Experiment Video

Updated: Jan 24, 2026

Gene Editing of Primary Rhesus Macaque B Cells
09:53

Gene Editing of Primary Rhesus Macaque B Cells

Published on: February 10, 2023

2.9K

Cynomolgus macaque IL37 polymorphism and control of SIV infection

Takashi Shiina1, Shingo Suzuki1, Nicolas Congy-Jolivet2,3

  • 1Department of Molecular Life Sciences, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Scientific Reports
|May 30, 2019
PubMed

Insights

Genetic variations, specifically a non-synonymous single nucleotide polymorphism (NS-SNP) in the IL37 gene, are significantly associated with controlling simian immunodeficiency virus (SIV) plasma virus load in macaques.

Area of Science:

  • Genetics and Immunology
  • Virology
  • Animal Models

Background:

  • Simian immunodeficiency virus (SIV) infection in Mauritian macaques serves as a model for studying human immunodeficiency virus (HIV).
  • Plasma virus load at set point (SP-PVL) is a critical determinant of disease progression in SIV-infected macaques.

Purpose of the Study:

  • To investigate the association between gene polymorphisms and SP-PVL in Mauritian macaques.
  • To identify genetic factors influencing viral load during chronic SIV infection.

Main Methods:

  • Sequencing of candidate genes in macaques with high and low SP-PVL.
  • Genotyping of non-synonymous single nucleotide polymorphisms (NS-SNPs) associated with PVL.
  • Multiple linear regression modeling to identify predictors of SP-PVL.

Main Results:

  • One NS-SNP in exon 1 of the IL37 gene showed a significant association with SP-PVL (p=3.33×10⁻⁴) and a high odds ratio (19.52).
  • IL37 exon 1 NS-SNP, MHC Class IB haplotypes M2 and M6 were significant predictors of SP-PVL.
  • These three factors explained 48% of the PVL variance (p=4.8×10⁻⁶).

Conclusions:

  • The IL37 gene polymorphism is a significant predictor of SIV plasma virus load in Mauritian macaques.
  • IL37 may play a role in controlling SIV infection.
  • Combined genetic factors significantly influence viral load set point in SIV infection.

More Related Videos

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques11:06

Laparoscopic Technique for Serial Collection of Liver and Mesenteric Lymph Nodes in Macaques

Published on: May 2, 2017

51.6K
Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques13:13

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

11.1K

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.0K
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
685
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
160
Control System Problem01:21

Control System Problem

In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
421
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
12.0K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
417