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The Novel HLA-DQA1*05:01:14 Allele Characterised by Two Different Sequencing-Based Typing Techniques.
Adèle Dhuyser1,2, Michaël Pérès1, Thomas Morel1
1HLA and Histocompatibility Laboratory, CHRU de Nancy, Vandœuvre-lès-Nancy, France.
HLA
|May 5, 2025
Summary
A new Human Leukocyte Antigen (HLA) allele, HLA-DQA1*05:01:14, has been identified. It differs from a known allele by a single synonymous nucleotide substitution in exon 3.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system plays a crucial role in immune responses.
- Accurate HLA allele identification is vital for transplantation and disease association studies.
Purpose of the Study:
- To report the discovery and characterization of a novel HLA-DQA1 allele.
Main Methods:
- Sequence analysis of the HLA-DQA1 gene.
- Comparison with existing HLA allele databases.
Main Results:
- A novel allele, designated HLA-DQA1*05:01:14, was identified.
- This new allele differs from HLA-DQA1*05:01:01:01 by a single synonymous nucleotide substitution located in exon 3.
Conclusions:
- The identification of novel HLA alleles expands our understanding of HLA polymorphism.
- This finding contributes to the ongoing efforts in high-resolution HLA typing and immunogenetic research.
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