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Lymphocytic choriomeningitis virus meningitis after needlestick injury: a case report

Sarah Dräger1, Anna-Friederike Marx2, Fiona Pigny3

  • 11Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

Antimicrobial Resistance and Infection Control
|May 30, 2019
PubMed
Abstract

Insights

A laboratory worker developed lymphocytic choriomeningitis virus (LCMV) meningitis after a needlestick injury. This case underscores the critical need for stringent safety protocols in research labs handling LCMV to prevent severe infections.

Area of Science:

  • Virology
  • Infectious Diseases
  • Occupational Health

Background:

  • Needlestick injuries in research laboratories pose risks of life-threatening infections.
  • The lymphocytic choriomeningitis virus (LCMV) can cause severe illness, including meningitis, following occupational exposure.
  • Laboratories handling LCMV require robust safety measures to protect personnel.

Observation:

  • A laboratory worker contracted LCMV meningitis after a needlestick injury from a contaminated needle.
  • Symptoms included systemic illness and meningitis, confirmed by PCR and seroconversion.
  • Hospitalization was required due to the severity of the meningitis.

Findings:

  • This is the first reported case of PCR-documented LCMV meningitis following a needlestick injury.
  • Seroconversion confirmed LCMV infection, with a significant rise in specific IgM and later IgG antibodies.
  • The case demonstrates LCMV transmission via percutaneous injury.

Implications:

  • Highlights the potential severity of LCMV infection from occupational exposure.
  • Emphasizes the critical importance of adhering to established safety protocols in research settings.
  • Reinforces the need for vigilance and prevention strategies when working with pathogenic viruses like LCMV.
Keywords:
Accidental infectionLymphocytic choriomeningitis virusMeningitisNeedlestick injuryRT-PCR

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