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Quality of Life and Coping in Multiple Endocrine Neoplasia Type 2

Fernanda A Correa1, Evelin C Farias1, Luciana A Castroneves1

  • 1Instituto do Câncer do Estado de São Paulo, Disciplina de Endocrinologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Journal of the Endocrine Society
|May 30, 2019
PubMed

Insights

Multiple Endocrine Neoplasia type 2 (MEN2) patients face significant quality of life and psychosocial challenges due to RET mutations. This study explores these burdens and suggests strategies for improvement.

Area of Science:

  • Oncology
  • Genetics
  • Psychology

Background:

  • Multiple Endocrine Neoplasia type 2 (MEN2) is a genetic cancer syndrome caused by RET germline mutations.
  • Limited data exist on the quality of life and psychosocial distress in MEN2 patients.
  • RET mutation carriers experience challenges like fear, guilt, treatment side effects, and healthcare access issues.

Purpose of the Study:

  • To investigate the effects of genetic testing on the quality of life for MEN2 patients.
  • To identify lifelong physical and psychosocial challenges faced by individuals with MEN2.
  • To propose strategies for mitigating the burden of living with MEN2 and suggest future research directions.

Main Methods:

  • Review of existing literature on MEN2 patient experiences.
  • Analysis of challenges related to genetic testing and chronic cancer management.
  • Exploration of coping mechanisms and healthcare access barriers.

Main Results:

  • Patients with MEN2 experience significant fear, guilt, and distress related to their genetic condition and cancer.
  • Chronic and incurable nature of MEN2-associated cancers presents ongoing physical and psychosocial burdens.
  • Access to adequate healthcare and effective coping strategies are crucial for improving patient well-being.

Conclusions:

  • Genetic testing and living with MEN2 impose substantial lifelong physical and psychosocial challenges.
  • Proactive strategies are needed to minimize the burden of MEN2.
  • Further research is essential to enhance the health-related quality of life for MEN2 patients.
Keywords:
MEN2hyperparathyroidismmedullary thyroid carcinomapheochromocytomaquality of life

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