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Association Between Papillary Thyroid Cancer and Primary Aldosteronism in Individuals With Hypertension
Ana Alice W Maciel1, Debora L S Danilovic2,3, Ibere C Soares4
1Unidade de Adrenal, Laboratório de Endocrinologia Molecular e Celular LIM25, Divisão de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, 01246-903, Brazil.
The Journal of Clinical Endocrinology and Metabolism
|September 18, 2024
Summary
Primary aldosteronism (PA) is independently associated with papillary thyroid cancer (PTC) in patients with hypertension. This suggests PA screening in individuals with both conditions, irrespective of hypertension severity.
Area of Science:
- Endocrinology
- Oncology
Background:
- Aldosterone excess is linked to oxidative stress and cell proliferation.
- Previous research on primary aldosteronism (PA) and papillary thyroid cancer (PTC) lacked matched controls.
Purpose of the Study:
- To investigate the association between PA and PTC in patients with arterial hypertension (HT).
- Utilized a propensity score-matched, case-control design for robust analysis.
Main Methods:
- Recruited 137 patients with PTC and HT.
- Matched 137 HT patients as controls (1:1 ratio) based on age, sex, and BMI.
- Performed secondary analysis matching controls by HT stage.
Main Results:
- Initially, PA prevalence was similar (29.20% in PTC vs. 20.44% in controls).
- However, after matching for HT stage, PA prevalence was significantly higher in the PTC group (9.56% vs. controls, P < .0001).
- Papillary thyroid cancer was an independent predictor of PA (OR 5.88, P < .001) in multivariable analysis.
Conclusions:
- Papillary thyroid cancer is an independent factor associated with PA diagnosis in hypertensive individuals.
- Recommend PA screening for patients with both PTC and HT, regardless of HT severity.
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