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Effect of time delay of PDA closure on the aortic stiffness index and its relationship with cardiac function

Saud M Elsaughier1, Ramadan Ghaleb1, Hossam Mansour1

  • 1Cardiology Department, Aswan University, Egypt.

Cardiovascular Journal of Africa
|May 30, 2019
PubMed

Insights

Delayed closure of patent ductus arteriosus (PDA) in children increases aortic stiffness and impairs cardiac function. Early intervention before age one is crucial for better cardiovascular outcomes in pediatric PDA patients.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Physiology
  • Medical Interventions

Background:

  • Patent ductus arteriosus (PDA) leads to left heart volume overload.
  • Aortic stiffness is a significant factor in cardiovascular diseases, linked to hypertension and coronary artery disease.
  • Understanding the impact of delayed PDA closure on aortic stiffness and cardiac function is critical.

Purpose of the Study:

  • To investigate the effect of delayed patent ductus arteriosus (PDA) closure on aortic stiffness.
  • To assess the relationship between aortic stiffness and cardiac function before and after transcatheter PDA closure.
  • To determine if the timing of PDA closure influences aortic stiffness and cardiac health.

Main Methods:

  • A cohort of 60 children undergoing transcatheter PDA closure was studied.
  • Participants were divided into two groups: early closure (before age 1) and delayed closure (after age 1).
  • Aortic stiffness index (ASI) and cardiac function were evaluated before and after PDA closure.

Main Results:

  • Children with delayed PDA closure (Group B) exhibited significantly higher aortic stiffness index (ASI) compared to early closure (Group A).
  • Both PDA groups showed significantly higher ASI compared to a healthy control group.
  • Elevated aortic stiffness was observed even in cases of small-sized PDAs.

Conclusions:

  • Patent ductus arteriosus (PDA) is associated with elevated aortic stiffness, even in smaller cases.
  • Delayed closure of PDA, particularly after one year of age, significantly increases aortic stiffness.
  • Increased aortic stiffness due to delayed PDA closure is linked to impaired cardiac function.
Abstract

Keywords:
PDA closureaortic stiffness indexcardiac function

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