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Mantle Cell Lymphoma With Mantle Zone Growth Pattern.

Ji Yuan1, Shaoying Li2, Xin Liu3

  • 1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.

American Journal of Clinical Pathology
|May 30, 2019
PubMed
Summary
This summary is machine-generated.

Mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP) often presents incidentally and resembles reactive lymph nodes. Cyclin D1 staining is crucial for diagnosis, though its clinical significance remains unclear.

Keywords:
Cyclin D1Mantle cell lymphomaMantle zone growth patternSOX11

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma.
  • MCL with mantle zone growth pattern (MCL-MZGP) presents a diagnostic challenge due to its resemblance to reactive lymphoid hyperplasia.

Purpose of the Study:

  • To characterize the clinical and pathologic features of MCL-MZGP.
  • To identify diagnostic markers for MCL-MZGP.

Main Methods:

  • Analysis of clinicopathologic data from 35 MCL-MZGP cases across 12 centers.
  • Immunohistochemical staining for BCL2, CD5, cyclin D1, and SOX11.

Main Results:

  • MCL-MZGP cases were often diagnosed at advanced clinical stages (81%) or incidentally found (40%).
  • Morphologically, affected lymph nodes showed preserved architecture with expanded mantles containing lymphoma cells.
  • Immunohistochemistry revealed positivity for BCL2 (96%), CD5 (82%), cyclin D1 (100%), and SOX11 (89%).
  • No significant difference in overall survival was observed between observation and chemotherapy groups.

Conclusions:

  • MCL-MZGP is frequently incidentally identified and mimics reactive mantles.
  • Cyclin D1 immunostaining is essential for diagnosing suspicious cases.
  • The overall clinical significance of MCL-MZGP requires further investigation.