Obesity and hypertension contribute to prolong QRS complex duration among middle-aged adults

Obesity and hypertension are comorbid diseases, which influence cardiac structure, and are associated with increased risk for cardiovascular events. The QRS duration (QRSd) reflects ventricular depolarization, and increased QRSd is associated with poor cardiovascular outcomes. QRS duration may be influenced by obesity and HTN, and reflect the increased risk factor for poor cardiovascular outcomes. The purpose of this analysis was to assess the relations between obesity, hypertension, and the interaction between them on QRSd.

In this secondary data analysis, firefighters without documented cardiovascular disease in normal sinus rhythm were included. Twelve-lead 24-hr ECG Holter monitors measured mean QRSd. Body mass index (BMI) and resting blood pressure (BP) were measured and categorized. Univariate linear regression models were produced using BMI, BP, and the interaction between BMI and BP as factors associated with QRSd. Multivariate models adjusting for multiple covariates were also produced.

Seventy-seven firefighters were included and most (89.4%) were overweight or obese. After covariate adjustment, BMI (p = 0.028), BMI categorization (p = 0.020), and the interaction between BMI and systolic BP (p = 0.021) were associated with prolong QRSd.

Increased BMI and an interaction between BMI and systolic BP were independently associated with prolongation of the QRS complex. Determination of the underlying cardiac structures responsible prolongation of the QRSd is recommended for further research.