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Understanding How Membrane Surface Charge Influences Lipid Bicelle Adsorption onto Oxide Surfaces
Tun Naw Sut1, Joshua A Jackman2, Nam-Joon Cho1,3
1School of Materials Science and Engineering , Nanyang Technological University , 50 Nanyang Avenue 639798 , Singapore.
Langmuir : the ACS Journal of Surfaces and Colloids
|May 30, 2019
Summary
This study explores forming supported lipid bilayers (SLBs) using charged lipid bicelles on various oxide surfaces. Researchers found that surface interactions and lipid composition control SLB formation pathways.
Area of Science:
- Materials Science
- Biophysics
- Surface Chemistry
Background:
- Supported lipid bilayers (SLBs) are crucial for biomimetic surfaces.
- Current SLB fabrication often uses zwitterionic lipids and silica, limiting scope.
- Exploring charged lipids and diverse surfaces expands SLB applications.
Purpose of the Study:
- Investigate charged lipid bicelle adsorption on silicon dioxide, titanium oxide, and aluminum oxide.
- Determine how lipid composition and substrate influence adsorption pathways.
- Understand the role of interfacial forces in SLB formation.
Main Methods:
- Quartz crystal microbalance-dissipation (QCM-D) technique.
- Systematic investigation of charged lipid bicelle adsorption.
- Analysis of adsorption kinetics and bilayer formation.
Main Results:
- Observed diverse adsorption pathways: SLB formation, monotonic adsorption, or negligible adsorption.
- SLB formation was achievable on all substrates with specific lipid compositions.
- Adsorption trends varied by substrate, controllable via bicelle-substrate interaction strength.
Conclusions:
- Lipid bicelles offer versatile routes for SLB fabrication on various oxide surfaces.
- Electrostatic and hydration forces govern bicelle-substrate interactions.
- Interfacial forces are key to controlling bicelle adsorption pathways for SLB formation.
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