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Updated: Jan 24, 2026

Measuring and Altering Mating Drive in Male Drosophila melanogaster
Published on: February 15, 2017
Evolution of Mechanisms that Control Mating in Drosophila Males
Osama M Ahmed1, Aram Avila-Herrera2, Khin May Tun3
1Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA.
Abstract:
Genetically wired neural mechanisms inhibit mating between species because even naive animals rarely mate with other species. These mechanisms can evolve through changes in expression or function of key genes in sensory pathways or central circuits. Gr32a is a gustatory chemoreceptor that, in D. melanogaster, is essential to inhibit interspecies courtship and sense quinine. Similar to D. melanogaster, we find that D. simulans Gr32a is expressed in foreleg tarsi, sensorimotor appendages that inhibit interspecies courtship, and it is required to sense quinine. Nevertheless, Gr32a is not required to inhibit interspecies mating by D. simulans males. However, and similar to its function in D. melanogaster, Ppk25, a member of the Pickpocket family, promotes conspecific courtship in D. simulans. Together, we have identified distinct evolutionary mechanisms underlying chemosensory control of taste and courtship in closely related Drosophila species.
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