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Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population

Qin Li1,2, Peng Zhang3, Yanyun Wang1

  • 1Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Disease Markers
|May 31, 2019
PubMed
Abstract

Insights

Genetic variations in the AXIN1 gene are linked to bladder cancer (BC) risk. Specifically, AXIN1 polymorphisms may influence BC development and prognosis, with rs12921862 showing potential as a predictive factor.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Axis inhibition protein 1 (AXIN1) expression reduction is linked to poor differentiation in non-small-cell lung cancer.
  • The association between AXIN1 and bladder cancer (BC) remains unexplored.
  • This study investigates AXIN1 gene polymorphisms in relation to BC risk.

Purpose of the Study:

  • To explore the relevance of AXIN1 gene polymorphisms (rs12921862, rs1805105, rs370681) and their association with bladder cancer (BC).
  • To determine if specific AXIN1 single-nucleotide polymorphisms (SNPs) impact BC risk and patient prognosis.

Main Methods:

  • Genotyping of three AXIN1 tag single-nucleotide polymorphisms (SNPs) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • Analysis of data from 316 BC patients and 419 healthy controls.
  • Statistical analysis performed using SNPstats and SPSS software.

Main Results:

  • All three investigated AXIN1 SNPs (rs12921862, rs1805105, rs370681) were associated with an increased risk of BC.
  • The rs12921862 A allele demonstrated a protective effect and correlated with better prognosis in non-muscle-invasive bladder cancer (NMIBC) patients.
  • The rs370681 polymorphism was linked to high-grade bladder cancer.

Conclusions:

  • AXIN1 gene polymorphisms may play a role in bladder cancer (BC) susceptibility.
  • The rs12921862 polymorphism could serve as a potential prognostic biomarker for BC patients.

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