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Biocompatible Two-Dimensional Titanium Nanosheets for Multimodal Imaging-Guided Cancer Theranostics
Zhongjian Xie1, Shiyou Chen1, Yanhong Duo1
1SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering , Shenzhen University , Shenzhen 518060 , China.
ACS Applied Materials & Interfaces
|May 31, 2019
Summary
Two-dimensional titanium nanosheets show promise for cancer treatment. These nanomaterials offer excellent biocompatibility and efficient photothermal therapy (PTT) for dual-modal imaging-guided cancer diagnosis and treatment.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
- Oncology
Background:
- Two-dimensional (2D) nanomaterials show potential for photothermal therapy (PTT) in cancer treatment.
- Developing biocompatible and highly efficient 2D theranostic agents for cancer remains a challenge.
- Nanosized titanium (Ti) with biological functions is largely unexplored, despite bulk Ti's biocompatibility.
Purpose of the Study:
- To explore the potential of 2D Ti nanosheets (NSs) as a theranostic nanoplatform.
- To evaluate 2D Ti NSs for dual-modal computed tomography/photoacoustic (CT/PA) imaging-guided PTT.
- To assess the biocompatibility, imaging capabilities, and therapeutic efficacy of 2D Ti NSs for cancer.
Main Methods:
- Exfoliation of 2D Ti nanosheets (NSs) from bulk Ti.
- Characterization of Ti NSs for optical absorption and photothermal conversion efficiency.
- Evaluation of Ti NSs in dual-modal CT/PA imaging and PTT for cancer models.
Main Results:
- Successfully exfoliated 2D Ti NSs with excellent biocompatibility.
- Ti NSs exhibit strong light absorption (extinction coefficient: 20.8 L g-1 cm-1) and high photothermal conversion efficiency (61.5%).
- Ti NSs provide strong CT/PA imaging signals and demonstrate efficient cancer therapy via PTT.
Conclusions:
- 2D Ti nanosheets are a promising theranostic nanoplatform for dual-modal imaging-guided photothermal cancer therapy.
- The metallic property and light-heat-acoustic transformation of 2D Ti enable simultaneous diagnosis and treatment.
- This study opens new avenues for elemental transition-metal-based cancer theranostics.
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