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Updated: Jan 24, 2026
12:08
Ex Vivo Infection of Live Tissue with Oncolytic Viruses
Published on: June 25, 2011
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Achieving systemic delivery of oncolytic viruses
Claudia Hill1, Robert Carlisle1
1a Institute of Biomedical Engineering , University of Oxford , Oxford , UK.
Expert Opinion on Drug Delivery
|May 31, 2019
Summary
Oncolytic virotherapy (OV) shows promise but faces delivery challenges. Enhancing OV systemic delivery through viral modulation or tumor physiology alteration is crucial for broader cancer treatment applications.
Area of Science:
- Oncolytic virotherapy
- Cancer treatment
- Drug delivery systems
Background:
- Oncolytic viruses (OVs) selectively target and kill cancer cells, with some approved for intratumoral injection.
- Systemic delivery of OVs has been limited by immune neutralization and poor tumor penetration.
Purpose of the Study:
- To review techniques for enhancing oncolytic virus (OV) delivery.
- To address challenges identified in clinical trials of OV therapy.
Main Methods:
- Cataloging techniques to improve OV delivery.
- Analyzing clinical trial data to identify delivery challenges.
- Reviewing strategies to overcome suboptimal pharmacokinetics, immune responses, and tumor penetration.
Main Results:
- Clinical trials highlight the need for improved OV delivery strategies.
- Various techniques exist to enhance OV systemic delivery and tumor penetration.
Conclusions:
- Enhanced systemic delivery of OVs is essential for broader clinical application and patient benefit.
- Strategies include modulating OVs genetically or chemically and altering tumor physiology.
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