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Updated: Jan 24, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Catalytic Asymmetric Reactions of α-Isocyanoacetates and meso-Aziridines Mediated by an in-Situ-Generated Magnesium
Dan Li1, Linqing Wang1, Haiyong Zhu1
1Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences , Lanzhou University , Lanzhou 730000 , China.
Abstract:
A catalytic asymmetric ring-opening reaction between α-isocyanoacetates and meso-aziridines has been realized by developing an in-situ-generated magnesium catalytic method. Chiral oxazoline-OH ligands were employed in the magnesium catalyst and diphenylphosphinamide was improved as a powerful achiral additive in this reaction. The ring-opening products of the desired reaction were obtained in good chemical yields and enantioselectivities. Moreover, these enantio-enriched adducts can be smoothly transformed into tetrahydropyrimidines mediated by a silver salt under mild conditions.
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