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Published on: March 6, 2013
Natural Products Containing the Oxetane and Related Moieties Present Additional Challenges for Structure Elucidation:
Andrei G Kutateladze1, Tina Holt1, D Sai Reddy1
1Department of Chemistry and Biochemistry , University of Denver , Denver , Colorado 80208 , United States.
Abstract:
Analysis of published NMR data for natural products containing the oxetane moiety, with the help of a recently developed parametric/DFT hybrid computational method DU8+, has revealed that oxetanes and related compounds constitute yet another significant challenge in structure elucidation and stereochemistry assignment, as more than 30 structures required revision. The most common pitfalls are discussed, and revised structures are suggested for 26 natural products.
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