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Correlation between renin-angiotensin system (RAS) related genes, type 2 diabetes, and cancer: Insights from

Luciana Xavier Pereira1, Laryssa Cristina Alves da Silva1, Alexya de Oliveira Feitosa1

  • 1Federal University of Alagoas, Campus Arapiraca. Av. Manoel Severino Barbosa, Bom Sucesso, Arapiraca, AL, 57309-005, Brazil.

Molecular and Cellular Endocrinology
|May 31, 2019
PubMed

Insights

This study identifies novel biomarkers in type 2 diabetes and cancer by integrating multi-omics data. These findings offer new targets for early detection and therapy in associated cancers.

Area of Science:

  • Biomolecular mechanisms
  • Systems biology
  • Multi-omics integration

Background:

  • Type 2 diabetes mellitus (DM) is linked to increased cancer risk, but underlying molecular mechanisms are unclear.
  • The renin-angiotensin system (RAS) is implicated in DM-associated cancer risk.
  • An integrative multi-omics approach is needed to elucidate these complex relationships.

Purpose of the Study:

  • To identify novel reporter biomolecules and pathways linking type 2 diabetes and associated cancers.
  • To explore the role of RAS in cancer initiation and progression within the context of type 2 diabetes.
  • To discover potential systems biomarkers for screening and therapeutic targets.

Main Methods:

  • Meta-analysis of transcriptome data from type 2 diabetes and various cancers.
  • Integration of gene expression profiles with genome-scale biomolecular networks.
  • Pathway analysis and immunohistochemistry to identify and validate biomarkers at RNA, protein, and metabolite levels.

Main Results:

  • Novel biomarker candidates, including metabolites (aminoacyl-tRNA biosynthesis, ABC transporters), were identified.
  • Differentially expressed genes (DEGs) were detected in various tissues between normal and diabetic patients.
  • RAS-related genes and enriched cancer pathways were identified in pancreatic islets, blood, and skeletal muscle.
  • Discrepancies between mRNA and protein expression (e.g., EDNRB) highlight post-translational modifications.

Conclusions:

  • Metabolites involved in aminoacyl-tRNA biosynthesis and ABC transporters show potential as novel biomarkers and therapeutic targets.
  • The identified biomolecules and pathways offer significant potential for screening and therapeutic strategies in type 2 diabetes and cancer.
  • Further experimental and clinical analysis is warranted to validate these findings.
Keywords:
Cancer and strokeDiabetes mellitusRenin–angiotensin systemTCGA data

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