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New phthalide derivatives from the Biscogniauxia sp. and their activities
Yan-Ying Liu1, Huan Zhao2, Jun Xie1
1Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.
Fitoterapia
|May 31, 2019
Abstract:
Five new phthalide derivatives, biscogniphthalides A-D (1, 2, 3a/3b, and 4), were isolated from Biscogniauxia sp. (No. 69-8-7-1), along with one related known phthalide (5). Their structures were determined by comprehensive spectroscopic analyses, chemical derivatization, and quantum chemical ECD calculations. In addition, the anti-acetyl cholinesterase, antimicrobial, and anti-α-glucosidase activities of 1-5 were evaluated.