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Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
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Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
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Related Experiment Video

Updated: Jan 24, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Workflow Optimization for Ischemic Stroke in a Community-Based Stroke Center.

Amin Aghaebrahim1, Manuel F Granja1, Guilherme J Agnoletto1

  • 1Baptist Neurological Institute, Lyerly Neurosurgery/Baptist Health, Jacksonville, Florida, USA.

World Neurosurgery
|May 31, 2019
PubMed
Summary
This summary is machine-generated.

Implementing simple optimization strategies significantly reduced treatment delays for acute stroke reperfusion therapies in a community hospital. This led to faster door-to-puncture times and improved patient outcomes.

Keywords:
Endovascular treatmentReperfusionStrokeThrombectomyWorkflow

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Area of Science:

  • Neurology
  • Hospital Administration
  • Medical Workflow Optimization

Background:

  • Treatment delays in acute stroke care can negatively impact patient outcomes.
  • Nonacademic hospitals face unique challenges in optimizing emergency stroke treatment pathways.

Purpose of the Study:

  • To evaluate the impact of specific workflow optimization interventions on reducing treatment delays for acute ischemic stroke.
  • To assess the effect of these optimizations on clinical outcomes in a nonacademic hospital setting.

Main Methods:

  • Analysis of ischemic stroke patient data from pre- and post-intervention periods (1 year each).
  • Implementation of nine key interventions including improved emergency medical service notification, stroke alert triage, direct computed tomography (CT) transport, and 24/7 vascular neurologist coverage.
  • Focus on reducing workflow intervals for patients receiving intravenous tissue plasminogen activator and/or endovascular therapy.

Main Results:

  • A total of 279 patients were analyzed, with no significant differences in baseline characteristics between the pre- and post-optimization periods.
  • Significant reduction in door-to-puncture time (median 64 vs. 47 minutes, P=0.001) was observed in the post-optimization period.
  • An 8.4% increase in good clinical outcomes was noted in the post-optimization group.

Conclusions:

  • Simple optimization methods can significantly reduce workflow intervals for acute reperfusion therapies in nonacademic community hospitals.
  • These workflow improvements are associated with better clinical outcomes for stroke patients.