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Pain-induced alterations in the individual non-esterified fatty acids in serum
R Knitza1, R Clasen, F Fischer
1Physiologisch-Chemisches Institut der Johannes Gutenberg-Universität, D-6500 Mainz, Germany Institut für Anästhesiologie der Johannes Gutenberg-Universität, D-6500 Mainz G.F.R.
Abstract:
Changes of individual non-esterified fatty acids in serum were studied in 7 metabolically healthy patients, suffering from idiopathic trigeminal neuralgia, who underwent electrocoagulation of gasserian ganglion under neurolepthypalgesia. The mean concentration of fatty acids increased by about 40% during the strong surgical pain stimulus. The increased lipolysis affected all individual fatty acids in proportion to the ratio of their presence in adipose tissue. The mechanism of pain-induced activation of lipase and possible consequences of alterations in individual non-esterified fatty acids are discussed.