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Related Experiment Video

Updated: Jan 24, 2026

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[Anti-TNF alpha-induced eruptive nevi: Three cases].

C Mazaud1, M Breban2, E Mahé1

  • 1Service de dermatologie, hôpital Victo-Dupouy, 69, rue du Lieutenant-Colonel Prudhon, 95100 Argenteuil, France.

Annales De Dermatologie Et De Venereologie
|June 1, 2019
PubMed
Summary
This summary is machine-generated.

Eruptive melanocytic nevi (EMN) are rare but can occur after anti-tumor necrosis factor alpha (anti-TNF alpha) treatment. Dermatological monitoring and sun protection are crucial for patients on these therapies.

Keywords:
Anti-TNF alphaEruptive neviHidradenitis suppurativaHidrosadénite suppuréeMaladie de VerneuilNævus éruptifsProtection solaireSpondyarthriteSpondyloarthritisSun protection

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Area of Science:

  • Dermatology
  • Immunology
  • Oncology

Background:

  • Eruptive melanocytic nevi (EMN) are characterized by the sudden appearance of multiple nevi.
  • EMN has been linked to immunosuppression, certain drugs, and therapies.
  • This study investigates EMN in patients undergoing anti-tumor necrosis factor alpha (anti-TNF alpha) treatment.

Observation:

  • Three cases of EMN following anti-TNF alpha therapy are presented.
  • Case 1: Adalimumab for spondyloarthritis led to nevi on limbs and palm.
  • Case 2: Etanercept for spondyloarthritis caused nevi on the trunk.
  • Case 3: Infliximab for hidradenitis suppurativa resulted in pigmented lesions on the trunk and palm.

Findings:

  • All three patients developed EMN during anti-TNF alpha treatment.
  • No transformation to melanoma was observed during follow-up periods ranging from 4 months to 5 years.
  • EMN is a rare but documented side effect of anti-TNF alpha therapy.

Implications:

  • The occurrence of EMN in patients on anti-TNF alpha therapy necessitates dermatological surveillance.
  • Increased risk of cutaneous carcinoma associated with anti-TNF alpha treatment highlights the need for vigilance.
  • Patients receiving anti-TNF alpha agents should be advised on sun protection measures.