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Signet ring cell mesothelioma; A diagnostic challenge
1Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7N0W8, Canada.
Pathology, Research and Practice
|June 1, 2019
Summary
Signet ring cell mesothelioma is a rare cancer variant. Distinguishing it from other diseases with similar cell morphology requires careful diagnostic evaluation using various markers and techniques.
Area of Science:
- Pathology
- Oncology
- Cell Biology
Background:
- Signet ring cell mesothelioma is a rare epithelioid mesothelioma variant.
- It predominantly affects males and occurs in the pleura or peritoneum.
- Its unique morphology presents diagnostic challenges, mimicking other conditions.
Purpose of the Study:
- To highlight the diagnostic difficulties associated with signet ring cell mesothelioma.
- To discuss the differential diagnosis of this rare cancer variant.
- To outline key diagnostic tools and their limitations.
Main Methods:
- Review of published cases and diagnostic criteria for signet ring cell mesothelioma.
- Analysis of differential diagnostic considerations, including reactive and neoplastic mimics.
- Evaluation of the utility of immunohistochemistry, electron microscopy, and genetic testing.
Main Results:
- Signet ring cell morphology can lead to misdiagnosis if not carefully evaluated.
- Mucin stains have limited utility in diagnosing this condition.
- A panel of mesothelial and epithelial markers is often necessary but requires cautious interpretation.
- Electron microscopy and genetic testing are valuable for differentiation.
Conclusions:
- Accurate diagnosis of signet ring cell mesothelioma requires a comprehensive approach.
- Awareness of its mimickers and the judicious use of advanced diagnostic techniques are crucial.
- Further research into specific markers may improve diagnostic accuracy.
Keywords:
Diagnostic pitfallDifferential diagnosisElectron microscopyImmunohistochemistryMolecular studySignet ring cell mesotheliomaMore Related Videos
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