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Published on: January 7, 2019
SERUM OMENTIN-1 LEVELS AND ENDOTHELIAL DYSFUNCTION IN OBESITY
A R Çimen1, E T Cerit1, O T Iyidir1
1Gazi University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.
Introduction:
Our aim was to investigate the relationship between serum omentin-1 levels and endothelial dysfunction in obese patients.
Material And Methods:
We evaluated 50 obese patients, and age/gender matched 45 healthy non-obese subjects as controls. Oral glucose tolerance test, lipid parameters, uric acid levels, homeostatic model assessment-insulin resistance (HOMA-IR) index, serum omentin-1 levels and flow mediated dilatation (FMD) % were measured in all subjects. Body compositions were analyzed with bioelectrical impedance method using a Tanita Body Composition Analyzer and ViScan.
Results:
Serum omentin-1 levels were found significantly lower in obese population compared to the control subjects. FMD response was significantly decreased in obese population. There was a significant positive correlation between serum omentin-1 levels and FMD response (r=0.359, p<0.001). Serum omentin-1 levels were negatively correlated with body mass index (BMI), waist circumference, total fat percentage, visceral fat, fasting insulin and HOMA-IR index.
Conclusion:
Lower serum omentin-1 levels and decreased FMD response may be an early marker of endothelial dysfunction in obese patients.
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