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CORTISOL LEVELS AND SUICIDE IN BIPOLAR I DISORDER.
A Giurgiuca1, B Nemes2, S Schipor3
1"Carol Davila" University of Medicine and Pharmacy - Department of Psychiatry, Bucharest, Romania.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
Hypothalamic-pituitary-adrenal (HPA) axis activity, measured by cortisol, did not differ significantly across suicidal behaviors in bipolar I disorder. However, younger patients with suicidal ideation showed higher cortisol output.
Area of Science:
- Neuroscience
- Endocrinology
- Psychiatry
Background:
- Hypothalamic-pituitary-adrenal (HPA) axis irregularities are linked to bipolar disorder and suicidal behavior.
- Limited research exists on cortisol levels and suicidal behavior specifically within bipolar disorder.
Purpose of the Study:
- To compare HPA axis activity in bipolar I disorder (BPD I) patients with and without suicidal ideation/behavior.
- To analyze serum and salivary cortisol levels in relation to suicidal history.
Main Methods:
- Cross-sectional, observational study of 75 BPD I patients categorized by suicidal history.
- Multiple serum and salivary cortisol measurements over two days, including after dexamethasone administration.
- Data collected via MINI 6.0 and semi-structured questionnaires.
Main Results:
- Cortisol parameters did not significantly differ based on suicidal history in the overall BPD I sample.
- Patients with a history of suicidal ideation exhibited higher total cortisol output compared to those without suicidal behavior, particularly in the 18-40 age group.
- Age was a significant factor in the relationship between cortisol output and suicidal ideation.
Conclusions:
- Total daily cortisol output shows age-dependent variation concerning suicidal thoughts in individuals with bipolar I disorder.
- These findings highlight the complex interplay between HPA axis regulation, age, and suicidal ideation in BPD I.
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