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Related Experiment Videos

THE MULTIFARIOUS CUSHING'S - LESSONS FROM A CASE SERIES.

I Ilie1, V Ciubotaru2, A Tulin3

  • 1"C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|September 12, 2019
PubMed
Summary

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CRANIOPHARYNGIOMA - CLINICAL AND THERAPEUTIC OUTCOME DATA IN A MIXED COHORT OF ADULT AND PAEDIATRIC CASES.

Acta endocrinologica (Bucharest, Romania : 2005)·2019

Endogenous Cushing's syndrome, a rare condition, presents diverse clinical signs making diagnosis challenging. Early recognition and management of hypercortisolism are crucial for patient outcomes.

Area of Science:

  • Endocrinology
  • Internal Medicine

Background:

  • Endogenous Cushing's syndrome is a rare endocrine disorder with an incidence of 0.7-2.4 per million people annually.
  • Diagnosis can be challenging due to the pleomorphic clinical presentation of hypercortisolism.
  • Early recognition and management of hypercortisolism are vital to reduce patient morbidity and mortality.

Observation:

  • A series of 6 endogenous Cushing's syndrome cases with varied etiologies (4 Cushing's disease, 2 adrenal Cushing's syndrome) were assessed over a decade.
  • Cases included typical Cushing's disease, pseudo-Cushing's states, elusive Cushing's disease, mild autonomous cortisol hypersecretion, Cushing's syndrome in pregnancy, and Cushing's disease with thromboembolism.
  • Diverse clinical manifestations across dermatologic, cardiovascular, musculoskeletal, neuropsychiatric, and reproductive systems were observed.
Keywords:
Cushing’s disease.Cushing’s syndrome

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Findings:

  • The study highlights the diversity in clinical forms, diagnostic tools, and management strategies for endogenous Cushing's syndrome.
  • Particular diagnostic clues were identified across various systems, aiding in the recognition of different Cushing's syndrome subtypes.
  • Similarities and differences in laboratory and imaging findings were discussed, alongside a review of therapeutic options.

Implications:

  • Understanding the varied presentations of Cushing's syndrome is essential for timely diagnosis and effective treatment.
  • This case series underscores the importance of a comprehensive diagnostic approach considering diverse clinical and laboratory findings.
  • Tailored therapeutic strategies are necessary for managing the distinct subtypes of endogenous Cushing's syndrome.