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HYDROCEPHALY, SCHIZENCEPHALY, SPONDYLOCOSTAL DYSPLASIA, AND HYPOPARATHYROIDISM IN AN INFANT OF A DIABETIC MOTHER

L Ognean1, O Boanta1, G Visa2

  • 1"Lucian Blaga" University, Faculty of Medicine, Dept. of Neonatology, Sibiu, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed

Insights

Infants born to mothers with diabetes face significant risks, including rare conditions like persistent hypoparathyroidism and spondylocostal dysplasia. This case highlights the complex challenges and multidisciplinary care needed for these high-risk newborns.

Area of Science:

  • Neonatal Medicine
  • Pediatric Endocrinology
  • Medical Genetics

Background:

  • Maternal diabetes mellitus is a leading cause of pregnancy complications, increasing risks for neonatal morbidity and mortality.
  • Known neonatal complications include macrosomia, respiratory distress, metabolic disturbances, and congenital defects.

Observation:

  • A macrosomic infant born to a mother with uncontrolled diabetes experienced a complex postnatal course.
  • The infant presented with respiratory distress, hypoglycemia, persistent hypocalcemia, hyperphosphatemia, and hydrocephaly.

Findings:

  • The infant developed hypoparathyroidism, hydrocephaly, schizencephaly, and spondylocostal dysplasia, requiring ventriculoperitoneal shunting.
  • Despite interventions, the infant suffered seizures and recurrent respiratory infections, leading to demise at 5 months.

Implications:

  • This rare case underscores the challenges in managing infants with multiple congenital anomalies born to diabetic mothers.
  • A multidisciplinary approach is crucial for addressing the complex needs of these neonates.
  • Highlights the importance of maternal glycemic control and prenatal care in mitigating neonatal risks.
Abstract

Keywords:
diabetic motherhydrocephalyhypoparathyroidisminfantschizencephalyspondylocostal dysplasia

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