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ACTUALITIES IN THE MANAGEMENT OF SECONDARY HYPERPARATHYROIDISM DUE TO CHRONIC KIDNEY DISEASE IN CHILDREN

M Gafencu1,2, R M Steflea3,4

  • 1Nephrology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|February 15, 2024
PubMed

Insights

Secondary hyperparathyroidism (SPHT) is a common complication in pediatric chronic kidney disease (CKD). Understanding its factors and improving dietary adherence are key for effective management of this CKD-MBD component.

Area of Science:

  • Nephrology
  • Pediatric Endocrinology
  • Mineral and Bone Disorders

Background:

  • Pediatric chronic kidney disease (CKD) significantly impacts global health, causing considerable morbidity.
  • Secondary hyperparathyroidism (SPHT) is a frequent early complication of renal insufficiency, crucial for maintaining mineral balance.
  • SPHT is a key component of chronic kidney disease-mineral and bone disorder (CKD-MBD).

Purpose of the Study:

  • To review current data on secondary hyperparathyroidism (SPHT) in pediatric chronic kidney disease (CKD).
  • To highlight the multifactorial nature of SPHT development in pediatric CKD.
  • To emphasize the importance of early diagnosis and management strategies for SPHT in children with CKD.

Main Methods:

  • This review synthesizes recent findings on SPHT in pediatric CKD.
  • It focuses on the factors contributing to the development of SPHT.
  • The review examines challenges in managing SPHT, particularly dietary non-adherence.

Main Results:

  • SPHT frequently complicates early-stage renal insufficiency in children.
  • Dietary non-adherence presents a significant challenge for managing SPHT in pediatric CKD cases.
  • Understanding the contributing factors is vital for effective SPHT management.

Conclusions:

  • Secondary hyperparathyroidism (SPHT) is a critical complication in pediatric chronic kidney disease (CKD).
  • Effective management requires addressing multifactorial causes and improving patient adherence to dietary recommendations.
  • Further research and updated strategies are needed for optimal care of children with CKD and SPHT.

Keywords:
Children CKDsecondary hyper-parathyroidism

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