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CARDIOVASCULAR RISK FACTORS IN ADOLESCENTS: ROLE OF INSULIN RESISTANCE AND OBESITY.
J Lopez-Sandoval1, S Sanchez-Enriquez2, E A Rivera-Leon2
1"Fray Antonio Alcalde" Hospital Civil de Guadalajara, Department of Pediatric Endocrinology, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Jalisco, Mexico.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
Childhood obesity is linked to early insulin resistance (IR) and inflammation. Obese adolescents exhibit higher IR, dyslipidemia, and inflammatory markers, increasing risks for future heart disease and diabetes.
Area of Science:
- Pediatric Endocrinology
- Metabolic Health
- Cardiovascular Risk Factors
Background:
- Childhood obesity presents a significant public health challenge.
- Early insulin resistance (IR), inflammation, and oxidative stress are key characteristics.
- Persistent low-grade inflammation negatively impacts metabolic and cardiovascular health.
Purpose of the Study:
- To investigate the relationship between obesity, insulin resistance, and inflammatory markers in adolescents.
- To identify key metabolic and hormonal profiles associated with obesity and IR in this age group.
Main Methods:
- A transverse analytical study involving 83 adolescents.
- Participants were categorized based on HOMA-IR and BMI (obese/normal-weight, with/without IR).
- Comprehensive assessment of anthropometric, biochemical, immunological, and hormonal variables.
Main Results:
- The IR group showed significantly higher obesity, dyslipidemia, IL-6, and C-reactive protein levels.
- Obese adolescents had elevated insulin, HOMA-IR, inflammatory markers, and triglycerides, with lower HDL-C and adiponectin.
- Obesity markers positively correlated with IR and inflammation, and negatively with adiponectin.
Conclusions:
- Adolescent obesity is characterized by early IR, subclinical inflammation, dyslipidemia, and hypoadiponectinemia.
- These factors are potential early indicators of increased risk for coronary heart disease (CHD) and diabetes mellitus (DM).
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