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LSPR-based cholesterol biosensor using a tapered optical fiber structure.

Santosh Kumar1, Brajesh Kumar Kaushik1,2, Ragini Singh3

  • 1Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information Technology, Liaocheng University, Liaocheng 252059, Shandong, China.

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Summary
This summary is machine-generated.

This study introduces a novel localized surface plasmon resonance (LSPR) biosensor for precise cholesterol detection. The optical fiber sensor using gold nanoparticles (AuNPs) offers improved sensitivity and selectivity for diagnosing critical health conditions.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Accurate cholesterol measurement is crucial for diagnosing cardiovascular diseases and other serious health conditions.
  • Conventional electrochemical sensors for cholesterol detection often lack sufficient sensitivity and selectivity.
  • Existing methods necessitate advancements for more reliable and precise cholesterol level monitoring.

Purpose of the Study:

  • To develop and demonstrate a localized surface plasmon resonance (LSPR)-based biosensor for accurate cholesterol concentration measurement.
  • To enhance sensor sensitivity and selectivity using gold nanoparticles (AuNPs) and cholesterol oxidase (ChOx) on a tapered optical fiber probe.
  • To establish a novel biosensing platform for clinical cholesterol level analysis.

Main Methods:

  • Fabrication of a tapered optical fiber sensor probe functionalized with gold nanoparticles (AuNPs).
  • Immobilization of cholesterol oxidase (ChOx) onto the AuNPs-coated optical fiber.
  • Characterization of AuNPs using UV-visible spectrophotometry, transmission electron microscopy (TEM), and energy dispersive X-ray spectroscopy (EDS).
  • Confirmation of AuNPs coating via scanning electron microscopy (SEM).

Main Results:

  • The developed LSPR biosensor accurately measures cholesterol within the clinically relevant range of 0 to 10 mM.
  • The sensor exhibits a low limit of detection (LOD) of 53.1 nM for cholesterol.
  • Characterization confirmed the successful synthesis and uniform coating of AuNPs on the optical fiber probe.

Conclusions:

  • The developed tapered optical fiber LSPR biosensor offers a highly sensitive and selective platform for cholesterol detection.
  • This novel biosensor shows significant potential for early diagnosis and monitoring of cholesterol-related diseases.
  • The integration of AuNPs and ChOx on optical fibers provides a promising approach for advanced biochemical sensing applications.