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Related Concept Videos

What is a Mode?01:07

What is a Mode?

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The mode is one of the commonly used measures of a central tendency. It is defined as the most frequent value in a data set.
There can be more than one mode in a data set if multiple values have the same highest frequency. For instance, suppose that the Statistics exam scores of 20 students are: 50; 53; 59; 59; 63; 63; 72; 72; 72; 72; 72; 76; 78; 81; 83; 84; 84; 84; 90; 93. Here, the mode is 72, as it occurs most frequently, five times.
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Resonance02:52

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The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
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Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
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Full Support Modes
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MOSFET: Enhancement Mode01:22

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Enhancement-mode MOSFETs are pivotal components in electronics, distinguished by their capacity to act as highly efficient switches. They are part of the larger family of metal-oxide Semiconductor Field-Effect Transistors (MOSFETs). They are available in two types: p-channel and n-channel, each tailored to specific polarity operations.
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Modes of Standing Waves: II01:04

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The starting point for expressing the modes of standing waves is understanding the boundary conditions that the waves must follow. The boundary conditions are derived from the physical understanding of how the standing waves are sustained, that is, how the vibrating particles of the medium behave at the boundaries imposed on them.
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Modes of Standing Waves - I01:03

Modes of Standing Waves - I

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A close look at earthquakes provides evidence for the conditions appropriate for resonance, standing waves, and constructive and destructive interference. A building may vibrate for several seconds with a driving frequency matching the building's natural frequency of vibration; this produces a resonance that results in one building collapsing while the neighboring buildings do not. Often, buildings of a certain height are devastated, while other taller buildings remain intact. This...
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Updated: Jan 24, 2026

Microwave Photonics Systems Based on Whispering-gallery-mode Resonators
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Chirped guided-mode resonance biosensor.

Graham J Triggs1, Yue Wang1, Christopher P Reardon1

  • 1Department of Physics, University of York, York YO10 5DD, UK.

Optica
|June 1, 2019
PubMed
Summary
This summary is machine-generated.

A novel chirped guided-mode resonant grating biosensor simplifies biomedical diagnostics. This low-cost, highly sensitive device translates spectral to spatial information for easy readout, enabling point-of-care applications.

Keywords:
(050.2770) Gratings(050.5745) Resonance domain(050.6624) Subwavelength structures(280.1415) Biological sensing and sensors(280.4788) Optical sensing and sensors

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Optical Sensors

Background:

  • Advanced biomedical diagnostic technologies are crucial for public health.
  • Current lab-on-a-chip technologies often require complex instrumentation, limiting field and clinical use.
  • Existing biosensors can be difficult to package due to light coupling requirements.

Purpose of the Study:

  • To introduce a novel biosensor utilizing a chirped guided-mode resonant grating.
  • To combine sensing and readout functions into a single device.
  • To develop a cost-effective and autonomous biosensing platform for point-of-care applications.

Main Methods:

  • Fabrication of a chirped guided-mode resonant grating.
  • Integration of sensing and readout functionalities.
  • Translation of spectral information into spatial information for CMOS camera readout.

Main Results:

  • Demonstrated refractive index sensitivity of 137 nm/RIU.
  • Achieved an extrapolated limit of detection of 267 pM for immunoglobulin G antibody binding.
  • Developed a biosensor with autonomous operation and high sensitivity.

Conclusions:

  • The chirped guided-mode resonance approach offers a new paradigm for biomedical sensing.
  • The developed biosensor is highly sensitive, autonomous, and cost-effective.
  • This technology has the potential to revolutionize point-of-care diagnostics.