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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes
Liam Connah, Rajendra Joshi, Sandip Vibhute
1Centro de Ciências e Tecnologias Nucleares, Departamento de Engenharia e Ciências Nucleares , Instituto Superior Técnico, Universidade de Lisboa , CTN, Bobadela LRS , Portugal.
Abstract:
The development of bifunctional imaging probes can often be challenging with difficult and time-consuming solution phase chemistry protocols and purification techniques. A solid phase synthetic protocol was therefore utilized to produce a functionalized derivative of a potent bismacrocyclic calcium-responsive contrast agent for magnetic resonance imaging. Through a convenient building block approach, the applicability of this methodology in the preparation and simple future development of multifunctional imaging probes was demonstrated.
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