Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Communication01:03

Communication

8.7K
Communication between two animals occurs when one animal transmits an information signal that causes a change in the animal that receives the information. Organisms communicate with one another in a host of different ways. Signals can be auditory, chemical, visual, tactile, or a combination of these. Communication is a critical behavioral adaptation that promotes survival, growth, and reproduction.
8.7K
Communication01:28

Communication

9.6K
Sharing information, concepts, and emotions to foster mutual understanding is communication. The sender, recipient, and transaction must be considered in this manner. The sender is the person who shares the message, the recipient is the person who receives and understands the message, and the transaction is the method used to deliver the message and the variables that affect the communication's context and surroundings. The nurse-client connection is built on therapeutic communication.
9.6K
What is Cell Signaling?02:03

What is Cell Signaling?

129.9K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
129.9K
What is Behavior?00:54

What is Behavior?

10.2K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.2K
Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
What are Cells?01:07

What are Cells?

197.8K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
197.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.

Nature communications·2026
Same author

Ultra-large targeted DNA integrations in primary human cells.

bioRxiv : the preprint server for biology·2026
Same author

Structural Dynamics of the Afamin/Wnt3a Complex Mediated by the Afamin Hydrophobic Pocket.

Nano letters·2026
Same author

DROP-CARs: Engineering Reversible, Drug-Controlled CAR T Cell Activity with a Clinically Approved Small Molecule.

Cancer research·2026
Same author

Spike-in probe-enhanced single-cell RNA-seq reveals post-infusion transcriptomic remodeling of "prime-and-kill" synNotch-CAR-T cells.

bioRxiv : the preprint server for biology·2026
Same author

NOT-gated chimeric antigen receptor circuits in T and NK cells.

Cell systems·2026
Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026
Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026
Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026
Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026
Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026
Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.1K

Engineering cell-cell communication networks: programming multicellular behaviors.

Satoshi Toda1, Nicholas W Frankel1, Wendell A Lim1

  • 1Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, and Center for Systems and Synthetic Biology, University of California San Francisco, San Francisco, CA 94158, USA.

Current Opinion in Chemical Biology
|June 1, 2019
PubMed
Summary
This summary is machine-generated.

Researchers are engineering synthetic cell-cell communication systems using synthetic biology. These engineered systems aim to control cellular behaviors for applications in cell-based therapeutics and understanding multicellular systems.

More Related Videos

Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

11.8K
Engineering Cell-permeable Protein
21:08

Engineering Cell-permeable Protein

Published on: December 28, 2009

15.0K

Related Experiment Videos

Last Updated: Jan 24, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

15.1K
Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

11.8K
Engineering Cell-permeable Protein
21:08

Engineering Cell-permeable Protein

Published on: December 28, 2009

15.0K

Area of Science:

  • Synthetic biology
  • Cellular communication
  • Multicellular systems biology

Background:

  • Cell-cell communication is fundamental to multicellular organisms, governing processes in development and immunity.
  • Genetic studies have identified key molecular components of these communication pathways.
  • Synthetic biology tools are being developed to engineer and control cellular sensing and responses.

Purpose of the Study:

  • To engineer novel cell-cell communication systems with design-based regulatory features.
  • To build and test synthetic cellular networks for understanding multicellular behaviors.
  • To explore applications of engineered cell-cell communication in cell-based therapeutics.

Main Methods:

  • Utilizing identified molecular components of cell-cell communication pathways.
  • Developing and applying synthetic biology tools for cellular control.
  • Constructing and analyzing synthetic cellular networks.

Main Results:

  • Successfully engineered new cell-cell communication with design-based regulatory features.
  • Built and tested synthetic cellular networks to understand multicellular biological principles.
  • Demonstrated potential for programming desired biological behaviors.

Conclusions:

  • Engineered cell-cell communication offers new capabilities for controlling cellular functions.
  • Synthetic cellular networks advance the understanding of multicellular behaviors.
  • These approaches hold promise for future cell-based therapeutic applications.