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Updated: Jan 24, 2026

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
Published on: February 23, 2016
Digital instrument with configurable hardware and firmware for multi-channel time measures
Nicola Lusardi1, Fabio Garzetti1, Angelo Geraci1
1Politecnico di Milano, Department of Electronics, Information and Bioengineering-DEIB, Via Camillo Golgi 40, Milan, MI 20133, Italy.
Abstract:
A new digital instrument for timing of events is presented. It is based on a reconfigurable, high-performance, 16-channel time-to-digital converter implemented in a Xilinx 7 Series 28-nm field programmable gate array device. Each channel provides timestamps with a least significant bit of 2 ps that states the resolution, whereas instead the single-shot precision is below 12.5 ps rms with the possibility of multihit measures at the maximum rate of 20 MHz. The default width of the full-scale range is 157 µs that can be extended at users choosing up to 15 days by means of proper time tagging procedures made available. The instrument achieves performance in terms of precision, resolution, and full-scale range of measurement at the state-of-art of existing solutions. The novelty is that besides performance, the presented instrument is totally reconfigurable by the user both in the hardware and in the firmware parts. Moreover, novel techniques of event acquisition (e.g., level-zero trigger) are introduced. These further features are not present in any other instrument available nor in the literature or in commerce and constitute a difference with respect to all referenced instruments.
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