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Saccadic fatigability in the oculomotor system.

J A Nij Bijvank1, L J van Rijn2, M Kamminga3

  • 1Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam, de Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Ophthalmology, Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam, de Boelelaan 1117, Amsterdam, the Netherlands.

Journal of the Neurological Sciences
|June 3, 2019
PubMed
Summary
This summary is machine-generated.

Repeated saccadic eye movements offer a reproducible method to measure oculomotor fatigability in multiple sclerosis (MS). However, this objective measure showed limited utility in reflecting perceived fatigue in MS patients.

Keywords:
Eye movementsFatigueInternuclear ophthalmoplegiaMultiple sclerosisOcular motility disordersSaccades

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Fatigue is a common and disabling symptom in multiple sclerosis (MS).
  • Quantifying fatigue in MS patients is challenging.
  • Oculomotor fatigability via saccadic eye movements is explored as a potential objective measure.

Purpose of the Study:

  • To investigate if repeated saccadic eye movements can measure oculomotor fatigability in MS.
  • To determine if oculomotor fatigability reflects perceived fatigue in MS patients.

Main Methods:

  • A prospective study using infrared oculography (DEMoNS) protocol.
  • Quantified saccades in MS patients (n=181) and healthy controls (n=58) using first and repeated pro-saccadic tasks (FPT & RPT).
  • Assessed perceived fatigue using Checklist Individual Strength and Neurological Fatigue Index (NFI); analyzed relationships using linear regression.

Main Results:

  • Significant changes in saccadic parameters (e.g., latency) were observed from FPT to RPT.
  • Saccadic latency showed a significant relationship with the NFI summary score, though this was weakened after adjusting for Expanded Disability Status score.
  • No significant group differences were found in the changes of saccadic parameters between MS patients and controls.

Conclusions:

  • An objective and reproducible method for measuring saccadic fatigability was established.
  • Saccadic fatigability demonstrated limited utility in reflecting perceived fatigue in multiple sclerosis.
  • Further investigation is recommended for conditions directly affecting ocular muscles or the neuromuscular junction.