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Related Experiment Videos

Survival experience in the Breast Cancer Detection Demonstration Project.

H Seidman1, S K Gelb, E Silverberg

  • 1Department of Epidemiology and Statistics, American Cancer Society, New York, New York.

CA: a Cancer Journal for Clinicians
|September 1, 1987
PubMed
Summary
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Mammography screening for breast cancer significantly improves survival rates in women of all ages, including those in their 40s. This study confirms its effectiveness, showing higher survival compared to other programs.

Area of Science:

  • Oncology
  • Radiology
  • Public Health

Background:

  • Breast cancer screening aims to detect cancer early for improved outcomes.
  • Mammography is a key screening tool, with established benefits for women over 50.
  • Evidence for mammography's effectiveness in younger women remains a subject of investigation.

Purpose of the Study:

  • To evaluate the long-term survival rates of women diagnosed with breast cancer in the Breast Cancer Detection Demonstration Project (BCDDP).
  • To compare the effectiveness of mammography screening in women in their 40s versus women in their 50s.
  • To assess the impact of screening on breast cancer stage at diagnosis and subsequent survival rates.

Main Methods:

  • Analysis of survival data from 4,240 women in the BCDDP with histologically confirmed breast cancer.

Related Experiment Videos

  • Comparison of BCDDP screening data with data from the National Cancer Institute's Surveillance, Epidemiology and End Results (NCI SEER) program.
  • Internal analyses to account for lead-time and length-time biases, and potential overdiagnosis.

    • Main Results:

    • High relative survival rates observed: 88% at 5 years, 83% at 8 years, and 79% at 10 years.
    • Screening demonstrated virtually equal effectiveness in detecting breast cancer and achieving survival in women aged 40s and 50s.
    • BCDDP participants showed significantly higher 5-year (87% vs. 74%) and 8-year (81% vs. 65%) survival rates for invasive cancers compared to SEER data.

    Conclusions:

    • Mammography screening is highly effective for breast cancer detection and improving survival in both younger (40s) and older (50s) women.
    • Screening leads to earlier diagnosis and treatment at more favorable stages, substantially increasing survival.
    • The BCDDP results indicate a significant reduction in case fatality rates due to early detection through mammography screening.