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Dosage form preference consultation study in children and young adults: paving the way for patient-centred and

Hamad Alyami1, Eman Dahmash1, Fahad Alyami2

  • 1Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham, UK.

European Journal of Hospital Pharmacy : Science and Practice
|June 4, 2019
PubMed

Insights

Orally disintegrating tablets (ODTs) are preferred by children and young adults over liquids. Key ODT characteristics for formulation include disintegration time, taste, size, and flavor.

Area of Science:

  • Pharmaceutical Sciences
  • Pediatric Pharmacology
  • Drug Delivery Systems

Background:

  • Orally disintegrating tablets (ODTs) offer advantages for pediatric drug administration.
  • Understanding patient preferences is crucial for successful formulation development.

Purpose of the Study:

  • To evaluate dosage form preferences in children and young adults.
  • To identify key characteristics for formulating effective ODTs.

Main Methods:

  • International, multisite, cross-sectional questionnaire study.
  • Involved children and young adults aged 6-18 years in the UK, Saudi Arabia, and Jordan.
  • Questionnaires were self-completed under supervision.

Main Results:

  • ODTs were the most preferred dosage form (58%), followed by liquids (20%).
  • Preferred ODT attributes include small size (<8mm), round shape, pink or white color, and strawberry flavor.
  • Key ODT characteristics for formulation are disintegration time, taste, size, and flavor.

Conclusions:

  • Study findings support a shift towards ODTs for pediatric drug administration (ages 6+).
  • Data will guide formulators in prioritizing ODT development attributes.
Abstract

Keywords:
CLINICAL PHARMACYPAEDIATRICS

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