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Updated: Jan 24, 2026

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Circular RNA 0047905 acts as a sponge for microRNA4516 and microRNA1227-5p, initiating gastric cancer progression

Zhiyong Lai1, Yang Yang2, Chaobing Wang2

  • 1a Department of General Surgery , Shanxi Dayi Hospital, Shanxi Academy of Medical Sciences , Taiyuan , Shanxi , People's Republic of China.

Cell Cycle (Georgetown, Tex.)
|June 4, 2019
PubMed

Insights

Circular RNA 0047905 promotes gastric cancer (GC) by regulating specific microRNAs and target genes. Downregulation of this circular RNA inhibits tumor progression and key signaling pathways, suggesting its potential as a GC biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are implicated in oncogenesis and tumor progression.
  • The specific roles of circRNAs in gastric cancer (GC) pathogenesis are not fully understood.

Purpose of the Study:

  • To investigate the role of circular RNA 0047905 (circRNA0047905) in gastric cancer.
  • To explore circRNA0047905 as a potential tumor promoter in GC.

Main Methods:

  • Profiling miRNA expression in GC and adjacent non-cancerous tissues using miRNA microarrays.
  • Constructing a competing endogenous RNA (ceRNA) network.
  • Investigating direct interactions between circRNA0047905, miRNAs (miR4516, miR1227-5p), and target mRNAs (SERPINB5, MMP11).
  • Assessing the impact of circRNA0047905 on the Akt/CREB signaling pathway.
  • Utilizing RNA scope in situ hybridization for expression analysis.

Main Results:

  • circRNA0047905 directly binds to miR4516 and miR1227-5p, consequently upregulating their targets SERPINB5 and MMP11.
  • Downregulation of circRNA0047905 in GC cells suppressed the activation of the Akt/CREB signaling pathway.
  • circRNA0047905 expression was detected in GC tissues.

Conclusions:

  • circRNA0047905 functions as a tumor promoter in gastric cancer.
  • circRNA0047905 may serve as a valuable diagnostic and therapeutic target for GC.
Keywords:
circRNA0047905competing endogenous RNAgastric canceroncogenesis

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