Related Experiment Video

Updated: Jan 24, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.3K

Laminin-derived peptides: Applications in drug delivery systems for targeting

Yoichi Negishi1, Motoyoshi Nomizu2

  • 1Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Pharmacology & Therapeutics
|June 4, 2019
PubMed

Insights

Laminin-derived peptides offer a promising targeting strategy for advanced drug delivery systems (DDSs). These peptides enhance the selective delivery of anticancer drugs and gene therapies to cancer cells, improving treatment efficacy.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Drug delivery systems (DDSs) are crucial for effective anticancer drugs and gene therapy.
  • Selective delivery of therapeutic agents to cancer cells remains a significant challenge.
  • Laminins, basement membrane proteins, contain peptides that interact with cellular receptors.

Purpose of the Study:

  • To review the progress of laminin-derived peptide-conjugated DDSs.
  • To highlight the role of these DDSs in cancer therapy and diagnostics.
  • To discuss the application of laminin peptides in targeted drug and gene delivery.

Main Methods:

  • Review of existing literature on laminin-derived peptide DDSs.
  • Analysis of targeting strategies utilizing laminin peptides.
  • Examination of applications in chemotherapy, gene therapy, and diagnostics.

Main Results:

  • Laminin-derived peptides serve as effective targeting moieties for DDSs.
  • These peptides enable selective binding to cancer cells and neovasculature.
  • Applications include drug carriers, gene carriers, and ultrasound contrast agents.

Conclusions:

  • Laminin-derived peptide-conjugated DDSs show significant potential for cancer treatment.
  • Enhanced selectivity improves the efficacy and reduces side effects of therapies.
  • These DDSs are valuable tools for both therapeutic and diagnostic applications in oncology.
Keywords:
Drug delivery systemLamininNanocarriersPeptideTargeting liposomes

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.5K
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.7K

Related Concept Videos

Control Systems: Applications01:25

Control Systems: Applications

Electrical engineering plays a pivotal role in our daily lives, with control systems at the heart of many applications, from home appliances to sophisticated space shuttles. Control systems manage and regulate the behavior of devices and processes, ensuring they function safely, correctly, and efficiently.
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
1.1K
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
755
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.7K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.6K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.1K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
752