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Updated: Jan 24, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

Renato B Pereira1, Nikolai M Evdokimov2, Florence Lefranc3

  • 1REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. ren.pereira@gmail.com.

Marine Drugs
|June 5, 2019
PubMed

Insights

Marine environments yield promising anticancer drugs, offering new hope for intractable cancers. The marine pharmaceutical pipeline includes approved drugs and agents in clinical trials, advancing cancer treatment.

Area of Science:

  • Marine biotechnology
  • Drug discovery and development
  • Oncology

Background:

  • The marine environment is a rich source for novel anticancer drug discovery.
  • Recent years have seen increased focus on marine-derived anticancer agents.
  • Clinical benefits and paradigm shifts in chemotherapy are often overlooked.

Purpose of the Study:

  • To highlight the clinical innovations and benefits of marine-derived anticancer agents.
  • To emphasize the scientific gains from marine drug discovery, including new mechanisms and targets.
  • To provide an overview of the current marine-derived anticancer pharmaceutical pipeline.

Main Methods:

  • Review of existing literature on marine-derived anticancer drugs.
  • Analysis of the current pharmaceutical pipeline, including approved drugs and clinical trials.
  • Assessment of scientific contributions, such as novel mechanisms of action and molecular targets.

Main Results:

  • Marine-derived anticancer agents have led to significant breakthroughs in chemotherapy.
  • Drug discovery from marine sources has yielded new anticancer mechanisms and molecular targets.
  • The current pipeline includes four approved drugs and eighteen agents in clinical trials, with six in late development.

Conclusions:

  • The marine pharmaceutical pipeline offers new therapeutic options for difficult-to-treat cancers.
  • Marine-derived anticancer agents represent a dynamic and evolving area of cancer treatment.
  • These agents provide renewed hope and advanced tools for cancer patients.
Keywords:
antibody–drug conjugatesbrentuximab vedotincytarabineeribulinlurbinectedinmarizomibplinabulinplitidepsinplocabulintrabectedin

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