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Updated: Jan 24, 2026

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
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Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

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Dextran-coated iron oxide nanoparticle for delivery of miR-29a to breast cancer cell line

Serap Yalcin1

  • 1a Department of Molecular Biology and Genetics , Kırşehir Ahi Evran University , Kırşehir , Turkey.

Pharmaceutical Development and Technology
|June 5, 2019
PubMed

Insights

Dextran-coated magnetic nanoparticles effectively deliver miR-29a to breast cancer cells, inhibiting tumor growth by down-regulating anti-apoptotic genes. This offers a promising new strategy for breast cancer therapy.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • MicroRNAs (miRNAs) are implicated in cancer pathways, with altered expression levels potentially inhibiting tumorigenesis.
  • Poor miRNA bioavailability due to enzymatic degradation hinders effective cancer therapy.
  • Targeted delivery of therapeutic miRNAs remains a significant challenge in oncology.

Purpose of the Study:

  • To design and evaluate dextran-coated iron oxide nanoparticles for targeted delivery of miR-29a to breast cancer cells.
  • To analyze the therapeutic efficacy of miR-29a-loaded nanoparticles in vitro.
  • To investigate the potential of this nanodelivery system for breast cancer treatment.

Main Methods:

  • Development of dextran-coated iron oxide nanoparticles.
  • Loading of miR-29a onto the nanoparticles.
  • In vitro assessment of selective delivery to breast cancer cells.
  • Analysis of gene expression, specifically focusing on anti-apoptotic genes.

Main Results:

  • The nanoparticles demonstrated enhanced selective delivery of miR-29a to breast cancer cells.
  • miR-29a delivered via nanoparticles led to the down-regulation of anti-apoptotic genes.
  • The nanocarrier system proved effective in vitro for miRNA delivery.

Conclusions:

  • Dextran-coated magnetic nanoparticles are a viable platform for targeted miR-29a delivery in breast cancer.
  • This approach shows potential for inhibiting cancer progression by modulating apoptosis-related genes.
  • Further research is warranted to explore the clinical application of miR-29a-loaded magnetic nanoparticles in breast cancer therapy.
Keywords:
MiR-29aapoptosisbreast cancerdextrannanoparticles

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