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Area of Science:

  • Pharmacy Practice
  • Mental Health Research
  • Public Health Interventions

Background:

  • Sub-threshold depression in patients with long-term conditions (LTCs) is prevalent and impacts quality of life.
  • Community pharmacies (CP) are accessible settings for delivering health interventions.
  • Existing primary care interventions for depression require adaptation for CP implementation.

Purpose of the Study:

  • To refine an enhanced support intervention (ESI) for CP staff to deliver to patients with sub-threshold depression and LTCs.
  • To develop and test study procedures for a pilot randomized controlled trial (RCT).
  • To evaluate the feasibility, acceptability, and potential effectiveness of the ESI in a community pharmacy setting.

Main Methods:

  • A feasibility study (case series/qualitative) refined the ESI and study procedures.
  • A pilot RCT (n=100) compared ESI to usual care, including process and economic evaluations.
  • Outcomes included depression severity (PHQ-9), participant acceptance, intervention uptake, retention, and cost-effectiveness.

Main Results:

  • The feasibility study successfully refined the ESI and study procedures.
  • The pilot RCT provided data on recruitment, intervention delivery, and study completion rates.
  • Qualitative data explored the acceptability and feasibility of ESI within community pharmacy.

Conclusions:

  • The enhanced support intervention (ESI) is a feasible and acceptable intervention for community pharmacies to deliver.
  • The pilot study successfully informed the design of a definitive RCT.
  • Community pharmacies are a viable setting for delivering mental health support to patients with long-term conditions.